The Care and Prevention Programme has provided a comprehensive Primary Health Care service for homosexually active men (HAM) in South Australia since the beginning of 1998. 565 HAM have enrolled over that time, of whom 379 have so far undergone detailed health review an average of eighteen months after enrolment, 228 have been reviewed a second time an average of 36 months after enrolment and 88 have been reviewed a third time an average of 55 months after enrolment. Enrolment data for the Programme show a pattern of social and health disadvantage that identifies HAM participants as subject to serious health inequity when compared with SA men generally. The proportion of men reporting unprotected anal intercourse with a casual partner in the prior six months fell marginally from 12.4% at enrolment to 9.7% at first review [NS] but had returned to 11.1% by second review [n=210, repeated measures]. However, while the rate at enrolment was not significantly different from that in the roughly contemporaneous 1999 Adelaide Periodic Survey (12.1%), the rate at second review was significantly lower than that in the roughly contemporaneous 2001 Periodic (15.9%, P